Inhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instability

BACKGROUND: The telomerase enzyme is a viable target for anti-cancer therapy given the innate differences in telomerase activity between tumour cells and normal somatic cells. However, the time lag between telomerase inhibition and telomeres becoming critically short to trigger cell death, allows ca...

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Detalles Bibliográficos
Autores principales: Gurung, Resham L, Balakrishnan, Lakshmidevi, Bhattacharjee, Rabindra N, Manikandan, Jayapal, Swaminathan, Srividya, Hande, M Prakash
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907560/
https://www.ncbi.nlm.nih.gov/pubmed/20678253
http://dx.doi.org/10.1186/2041-9414-1-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907560/
https://www.ncbi.nlm.nih.gov/pubmed/20678253
http://dx.doi.org/10.1186/2041-9414-1-5

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