Otx2 Gene Deletion in Adult Mouse Retina Induces Rapid RPE Dystrophy and Slow Photoreceptor Degeneration

BACKGROUND: Many developmental genes are still active in specific tissues after development is completed. This is the case for the homeobox gene Otx2, an essential actor of forebrain and head development. In adult mouse, Otx2 is strongly expressed in the retina. Mutations of this gene in humans have...

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Detalles Bibliográficos
Autores principales: Béby, Francis, Housset, Michael, Fossat, Nicolas, Le Greneur, Coralie, Flamant, Frédéric, Godement, Pierre, Lamonerie, Thomas
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908139/
https://www.ncbi.nlm.nih.gov/pubmed/20657788
http://dx.doi.org/10.1371/journal.pone.0011673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908139/
https://www.ncbi.nlm.nih.gov/pubmed/20657788
http://dx.doi.org/10.1371/journal.pone.0011673

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