Identification of the Rheumatoid Arthritis Shared Epitope Binding Site on Calreticulin

BACKGROUND: The rheumatoid arthritis (RA) shared epitope (SE), a major risk factor for severe disease, is a five amino acid motif in the third allelic hypervariable region of the HLA-DRβ chain. The molecular mechanisms by which the SE affects susceptibility to – and severity of - RA are unknown. We...

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Detalles Bibliográficos
Autores principales: Ling, Song, Cheng, Andrew, Pumpens, Paul, Michalak, Marek, Holoshitz, Joseph
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908537/
https://www.ncbi.nlm.nih.gov/pubmed/20661469
http://dx.doi.org/10.1371/journal.pone.0011703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908537/
https://www.ncbi.nlm.nih.gov/pubmed/20661469
http://dx.doi.org/10.1371/journal.pone.0011703

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