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Identification of the Rheumatoid Arthritis Shared Epitope Binding Site on Calreticulin
BACKGROUND: The rheumatoid arthritis (RA) shared epitope (SE), a major risk factor for severe disease, is a five amino acid motif in the third allelic hypervariable region of the HLA-DRβ chain. The molecular mechanisms by which the SE affects susceptibility to – and severity of - RA are unknown. We...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908537/ https://www.ncbi.nlm.nih.gov/pubmed/20661469 http://dx.doi.org/10.1371/journal.pone.0011703 |