Tumor Associated Macrophages Protect Colon Cancer Cells from TRAIL-Induced Apoptosis through IL-1β- Dependent Stabilization of Snail in Tumor Cells

BACKGROUND: We recently reported that colon tumor cells stimulate macrophages to release IL-1β, which in turn inactivates GSK3β and enhances Wnt signaling in colon cancer cells, generating a self-amplifying loop that promotes the growth of tumor cells. PRINCIPAL FINDINGS: Here we describe that macro...

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Detalles Bibliográficos
Autores principales: Kaler, Pawan, Galea, Vincent, Augenlicht, Leonard, Klampfer, Lidija
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908545/
https://www.ncbi.nlm.nih.gov/pubmed/20661477
http://dx.doi.org/10.1371/journal.pone.0011700

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908545/
https://www.ncbi.nlm.nih.gov/pubmed/20661477
http://dx.doi.org/10.1371/journal.pone.0011700

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