The Role of Type 4 Phosphodiesterases in Generating Microdomains of cAMP: Large Scale Stochastic Simulations

Cyclic AMP (cAMP) and its main effector Protein Kinase A (PKA) are critical for several aspects of neuronal function including synaptic plasticity. Specificity of synaptic plasticity requires that cAMP activates PKA in a highly localized manner despite the speed with which cAMP diffuses. Two mechani...

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Detalles Bibliográficos
Autores principales: Oliveira, Rodrigo F., Terrin, Anna, Di Benedetto, Giulietta, Cannon, Robert C., Koh, Wonryull, Kim, MyungSook, Zaccolo, Manuela, Blackwell, Kim T.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908681/
https://www.ncbi.nlm.nih.gov/pubmed/20661441
http://dx.doi.org/10.1371/journal.pone.0011725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908681/
https://www.ncbi.nlm.nih.gov/pubmed/20661441
http://dx.doi.org/10.1371/journal.pone.0011725

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