Sex Reversal in Zebrafish fancl Mutants Is Caused by Tp53-Mediated Germ Cell Apoptosis

The molecular genetic mechanisms of sex determination are not known for most vertebrates, including zebrafish. We identified a mutation in the zebrafish fancl gene that causes homozygous mutants to develop as fertile males due to female-to-male sex reversal. Fancl is a member of the Fanconi Anemia/B...

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Detalles Bibliográficos
Autores principales: Rodríguez-Marí, Adriana, Cañestro, Cristian, BreMiller, Ruth A., Nguyen-Johnson, Alexandria, Asakawa, Kazuhide, Kawakami, Koichi, Postlethwait, John H.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908690/
https://www.ncbi.nlm.nih.gov/pubmed/20661450
http://dx.doi.org/10.1371/journal.pgen.1001034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908690/
https://www.ncbi.nlm.nih.gov/pubmed/20661450
http://dx.doi.org/10.1371/journal.pgen.1001034

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