Deficiency of Pten accelerates mammary oncogenesis in MMTV-Wnt-1 transgenic mice

BACKGROUND: Germline mutations in the tumor suppressor PTEN predispose human beings to breast cancer, and genetic and epigenetic alterations of PTEN are also detected in sporadic human breast cancer. Germline Pten mutations in mice lead to the development of a variety of tumors, but mammary carcinom...

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Detalles Bibliográficos
Autores principales: Li, Yi, Podsypanina, Katrina, Liu, Xiufan, Crane, Allison, Tan, Lee K, Parsons, Ramon, Varmus, Harold E
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29091/
https://www.ncbi.nlm.nih.gov/pubmed/11178110
http://dx.doi.org/10.1186/1471-2199-2-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC29091/
https://www.ncbi.nlm.nih.gov/pubmed/11178110
http://dx.doi.org/10.1186/1471-2199-2-2

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