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Cell cycle G2/M arrest through an S phase-dependent mechanism by HIV-1 viral protein R

BACKGROUND: Cell cycle G2 arrest induced by HIV-1 Vpr is thought to benefit viral proliferation by providing an optimized cellular environment for viral replication and by skipping host immune responses. Even though Vpr-induced G2 arrest has been studied extensively, how Vpr triggers G2 arrest remai...

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Detalles Bibliográficos
Autores principales: Li, Ge, Park, Hyeon U, Liang, Dong, Zhao, Richard Y
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909154/
https://www.ncbi.nlm.nih.gov/pubmed/20609246
http://dx.doi.org/10.1186/1742-4690-7-59