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Innate Immune Suppression Enables Frequent Transfection with RNA Encoding Reprogramming Proteins

BACKGROUND: Generating autologous pluripotent stem cells for therapeutic applications will require the development of efficient DNA-free reprogramming techniques. Transfecting cells with in vitro-transcribed, protein-encoding RNA is a straightforward method of directly expressing high levels of repr...

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Detalles Bibliográficos
Autores principales: Angel, Matthew, Yanik, Mehmet Fatih
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909252/
https://www.ncbi.nlm.nih.gov/pubmed/20668695
http://dx.doi.org/10.1371/journal.pone.0011756