Catalysis of the microtubule on-rate is the major parameter regulating the depolymerase activity of MCAK

The kinesin-13, MCAK, is a critical regulator of microtubule dynamics in eukaryotic cells1. We have functionally dissected the structural features responsible for MCAK’s potent microtubule depolymerization activity. MCAK’s positively charged neck enhances its delivery to microtubule ends, not by tet...

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Detalles Bibliográficos
Autores principales: Cooper, Jeremy R., Wagenbach, Michael, Asbury, Charles L., Wordeman, Linda
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909650/
https://www.ncbi.nlm.nih.gov/pubmed/19966798
http://dx.doi.org/10.1038/nsmb.1728

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909650/
https://www.ncbi.nlm.nih.gov/pubmed/19966798
http://dx.doi.org/10.1038/nsmb.1728

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