A synergistic small molecule combination directly eradicates diverse prion strain structures

Safely eradicating prions, amyloids and preamyloid oligomers may ameliorate several fatal neurodegenerative disorders. Yet, whether small-molecule drugs can directly antagonize the entire spectrum of distinct amyloid structures or ‘strains’ that underlie distinct disease states is unclear. Here, we...

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Detalles Bibliográficos
Autores principales: Roberts, Blake E., Duennwald, Martin L., Wang, Huan, Chung, Chan, Lopreiato, Nicholas P., Sweeny, Elizabeth A., Knight, M. Noelle, Shorter, James
Formato: Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909773/
https://www.ncbi.nlm.nih.gov/pubmed/19915541
http://dx.doi.org/10.1038/nchembio.246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909773/
https://www.ncbi.nlm.nih.gov/pubmed/19915541
http://dx.doi.org/10.1038/nchembio.246

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