PR1-Specific T Cells Are Associated with Unmaintained Cytogenetic Remission of Chronic Myelogenous Leukemia After Interferon Withdrawal

BACKGROUND: Interferon-α (IFN) induces complete cytogenetic remission (CCR) in 20–25% CML patients and in a small minority of patients; CCR persists after IFN is stopped. IFN induces CCR in part by increasing cytotoxic T lymphocytes (CTL) specific for PR1, the HLA-A2-restricted 9-mer peptide from pr...

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Detalles Bibliográficos
Autores principales: Kanodia, Shreya, Wieder, Eric, Lu, Sijie, Talpaz, Moshe, Alatrash, Gheath, Clise-Dwyer, Karen, Molldrem, Jeffrey J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909896/
https://www.ncbi.nlm.nih.gov/pubmed/20668669
http://dx.doi.org/10.1371/journal.pone.0011770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909896/
https://www.ncbi.nlm.nih.gov/pubmed/20668669
http://dx.doi.org/10.1371/journal.pone.0011770

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