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Hypoxia-specific targets in cancer therapy: role of splice variants
Tumour hypoxia is a well known adverse prognostic factor in the treatment of solid tumours. Hypoxia-inducible factor 1α (HIF-1α), a transcription factor subunit regulating a large number of hypoxia-responsive genes, is considered an attractive target for novel treatment approaches, due to a frequent...
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| Formato: | Texto |
| Lenguaje: | English |
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BioMed Central
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909930/ https://www.ncbi.nlm.nih.gov/pubmed/20624302 http://dx.doi.org/10.1186/1741-7015-8-45 |