Structure determination of DNA methylation lesions N(1)-meA and N(3)-meC in duplex DNA using a cross-linked protein–DNA system

N(1)-meA and N(3)-meC are cytotoxic DNA base methylation lesions that can accumulate in the genomes of various organisms in the presence of S(N)2 type methylating agents. We report here the structural characterization of these base lesions in duplex DNA using a cross-linked protein–DNA crystallizati...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Lianghua, Yi, Chengqi, Jian, Xing, Zheng, Guanqun, He, Chuan
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910035/
https://www.ncbi.nlm.nih.gov/pubmed/20223766
http://dx.doi.org/10.1093/nar/gkq129

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910035/
https://www.ncbi.nlm.nih.gov/pubmed/20223766
http://dx.doi.org/10.1093/nar/gkq129

Ejemplares similares