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Structure determination of DNA methylation lesions N(1)-meA and N(3)-meC in duplex DNA using a cross-linked protein–DNA system
N(1)-meA and N(3)-meC are cytotoxic DNA base methylation lesions that can accumulate in the genomes of various organisms in the presence of S(N)2 type methylating agents. We report here the structural characterization of these base lesions in duplex DNA using a cross-linked protein–DNA crystallizati...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910035/ https://www.ncbi.nlm.nih.gov/pubmed/20223766 http://dx.doi.org/10.1093/nar/gkq129 |