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A rationally designed peptide enhances homologous recombination in vitro and resistance to DNA damaging agents in vivo
The RecA family of proteins is essential in homologous recombination, a critical step in DNA repair. Here, we report that a rationally-designed small peptide based on the crystal structure of Escherichia coli RecA–DNA complex can promote homologous recombination through the enhancement of both RecA-...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910059/ https://www.ncbi.nlm.nih.gov/pubmed/20308162 http://dx.doi.org/10.1093/nar/gkq182 |