Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3β?

BACKGROUND: Male Irs2(-/- )mice develop fatal type 2 diabetes at 13-14 weeks. Defects in neuronal proliferation, pituitary development and photoreceptor cell survival manifest in Irs2(-/- )mice. We identify retarded renal growth in male and female Irs2(-/- )mice, independent of diabetes. RESULTS: Ki...

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Detalles Bibliográficos
Autores principales: Carew, Rosemarie M, Sadagurski, Marianna, Goldschmeding, Roel, Martin, Finian, White, Morris F, Brazil, Derek P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910663/
https://www.ncbi.nlm.nih.gov/pubmed/20604929
http://dx.doi.org/10.1186/1471-213X-10-73

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910663/
https://www.ncbi.nlm.nih.gov/pubmed/20604929
http://dx.doi.org/10.1186/1471-213X-10-73

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