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Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3β?
BACKGROUND: Male Irs2(-/- )mice develop fatal type 2 diabetes at 13-14 weeks. Defects in neuronal proliferation, pituitary development and photoreceptor cell survival manifest in Irs2(-/- )mice. We identify retarded renal growth in male and female Irs2(-/- )mice, independent of diabetes. RESULTS: Ki...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910663/ https://www.ncbi.nlm.nih.gov/pubmed/20604929 http://dx.doi.org/10.1186/1471-213X-10-73 |