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PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway
OBJECTIVE: Loss-of-function mutations in Perk (EIF2AK3) result in permanent neonatal diabetes in humans (Wolcott-Rallison Syndrome) and mice. Previously, we found that diabetes associated with Perk deficiency resulted from insufficient proliferation of β-cells and from defects in insulin secretion....
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Diabetes Association
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911049/ https://www.ncbi.nlm.nih.gov/pubmed/20530744 http://dx.doi.org/10.2337/db09-1064 |