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PERK (EIF2AK3) Regulates Proinsulin Trafficking and Quality Control in the Secretory Pathway

OBJECTIVE: Loss-of-function mutations in Perk (EIF2AK3) result in permanent neonatal diabetes in humans (Wolcott-Rallison Syndrome) and mice. Previously, we found that diabetes associated with Perk deficiency resulted from insufficient proliferation of β-cells and from defects in insulin secretion....

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Detalles Bibliográficos
Autores principales:	Gupta, Sounak, McGrath, Barbara, Cavener, Douglas R.
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911049/ https://www.ncbi.nlm.nih.gov/pubmed/20530744 http://dx.doi.org/10.2337/db09-1064

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