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Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius: Electrical Properties of Glucagon-Like Peptide 1 Neurons

OBJECTIVE: Glucagon-like peptide (GLP)-1 inhibits food intake, acting both in the periphery and within the central nervous system. It is unclear if gut-derived GLP-1 can enter the brain, or whether GLP-1 from preproglucagon (PPG) cells in the lower brainstem is required to activate central GLP-1 rec...

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Detalles Bibliográficos
Autores principales:	Hisadome, Kazunari, Reimann, Frank, Gribble, Fiona M., Trapp, Stefan
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2010
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911066/ https://www.ncbi.nlm.nih.gov/pubmed/20522593 http://dx.doi.org/10.2337/db10-0128

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