Deficiency in B7-H1 (PD-L1)/PD-1 Coinhibition Triggers Pancreatic β-Cell Destruction by Insulin-Specific, Murine CD8 T-Cells

OBJECTIVE: RIP-B7.1 mice expressing the costimulator molecule B7.1 (CD80) on pancreatic β-cells are a well established model to characterize preproinsulin-specific CD8 T-cell responses and experimental autoimmune diabetes (EAD). Different immunization strategies could prime preproinsulin-specific CD...

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Detalles Bibliográficos
Autores principales: Rajasalu, Tarvo, Brosi, Helen, Schuster, Cornelia, Spyrantis, Andreas, Boehm, Bernhard Otto, Chen, Lieping, Reimann, Jörg, Schirmbeck, Reinhold
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2010
Materias:
Immunology and Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911076/
https://www.ncbi.nlm.nih.gov/pubmed/20484136
http://dx.doi.org/10.2337/db09-1135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911076/
https://www.ncbi.nlm.nih.gov/pubmed/20484136
http://dx.doi.org/10.2337/db09-1135

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