Novel Antileukemic Compound Ingenol 3-Angelate Inhibits T Cell Apoptosis by Activating Protein Kinase Cθ

Members of the protein kinase C (PKC) family of serine-threonine kinases are important regulators of immune cell survival. Ingenol 3-angelate (PEP005) activates a broad range of PKC isoforms and induces apoptosis in acute myeloid leukemia cells by activating the PKC isoform PKCδ. We show here that,...

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Detalles Bibliográficos
Autores principales: Lee, Wing-yiu, Hampson, Peter, Coulthard, Lydia, Ali, Farrah, Salmon, Mike, Lord, Janet M., Scheel-Toellner, Dagmar
Formato: Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911273/
https://www.ncbi.nlm.nih.gov/pubmed/20472553
http://dx.doi.org/10.1074/jbc.M109.041962

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911273/
https://www.ncbi.nlm.nih.gov/pubmed/20472553
http://dx.doi.org/10.1074/jbc.M109.041962

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