A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors

BACKGROUND: Hyperactivation of the Ras signaling pathway is a driver of many cancers, and RAS pathway activation can predict response to targeted therapies. Therefore, optimal methods for measuring Ras pathway activation are critical. The main focus of our work was to develop a gene expression signa...

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Detalles Bibliográficos
Autores principales: Loboda, Andrey, Nebozhyn, Michael, Klinghoffer, Rich, Frazier, Jason, Chastain, Michael, Arthur, William, Roberts, Brian, Zhang, Theresa, Chenard, Melissa, Haines, Brian, Andersen, Jannik, Nagashima, Kumiko, Paweletz, Cloud, Lynch, Bethany, Feldman, Igor, Dai, Hongyue, Huang, Pearl, Watters, James
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911390/
https://www.ncbi.nlm.nih.gov/pubmed/20591134
http://dx.doi.org/10.1186/1755-8794-3-26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911390/
https://www.ncbi.nlm.nih.gov/pubmed/20591134
http://dx.doi.org/10.1186/1755-8794-3-26

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