Transcriptional regulation of human osteopontin promoter by histone deacetylase inhibitor, trichostatin A in cervical cancer cells

BACKGROUND: Trichostatin A (TSA), a potent inhibitor of histone deacetylases exhibits strong anti-tumor and growth inhibitory activities, but its mechanism(s) of action is not completely understood. Osteopontin (OPN) is a secreted glycoprotein which has long been associated with tumor metastasis. El...

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Detalles Bibliográficos
Autores principales: Sharma, Priyanka, Kumar, Santosh, Kundu, Gopal C
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911447/
https://www.ncbi.nlm.nih.gov/pubmed/20609221
http://dx.doi.org/10.1186/1476-4598-9-178