Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

The catalytic activity of the MPS1 kinase is crucial for the spindle assembly checkpoint and for chromosome biorientation on the mitotic spindle. We report that the small molecule reversine is a potent mitotic inhibitor of MPS1. Reversine inhibits the spindle assembly checkpoint in a dose-dependent...

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Detalles Bibliográficos
Autores principales: Santaguida, Stefano, Tighe, Anthony, D'Alise, Anna Morena, Taylor, Stephen S., Musacchio, Andrea
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911657/
https://www.ncbi.nlm.nih.gov/pubmed/20624901
http://dx.doi.org/10.1083/jcb.201001036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911657/
https://www.ncbi.nlm.nih.gov/pubmed/20624901
http://dx.doi.org/10.1083/jcb.201001036

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