Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

Mps1 is an essential component of the spindle assembly checkpoint. In this study, we describe a novel Mps1 inhibitor, AZ3146, and use it to probe the role of Mps1’s catalytic activity during mitosis. When Mps1 is inhibited before mitotic entry, subsequent recruitment of Mad1 and Mad2 to kinetochores...

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Detalles Bibliográficos
Autores principales: Hewitt, Laura, Tighe, Anthony, Santaguida, Stefano, White, Anne M., Jones, Clifford D., Musacchio, Andrea, Green, Stephen, Taylor, Stephen S.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911659/
https://www.ncbi.nlm.nih.gov/pubmed/20624899
http://dx.doi.org/10.1083/jcb.201002133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911659/
https://www.ncbi.nlm.nih.gov/pubmed/20624899
http://dx.doi.org/10.1083/jcb.201002133

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