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Calmodulin-dependent nuclear import of HMG-box family nuclear factors: importance of the role of SRY in sex reversal

The HMG (high-mobility group)-box-containing chromatin-remodelling factor SRY (sex-determining region on the Y chromosome) plays a key role in sex determination. Its role in the nucleus is critically dependent on two NLSs (nuclear localization signals) that flank its HMG domain: the C-terminally loc...

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Detalles Bibliográficos
Autores principales: Kaur, Gurpreet, Delluc-Clavieres, Aurelie, Poon, Ivan K. H., Forwood, Jade K., Glover, Dominic J., Jans, David A.
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911679/
https://www.ncbi.nlm.nih.gov/pubmed/20528776
http://dx.doi.org/10.1042/BJ20091758