The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

MPO (myeloperoxidase) catalyses the oxidation of chloride, bromide and thiocyanate by hydrogen peroxide to HOCl (hypochlorous acid), HOBr (hypobromous acid) and HOSCN (hypothiocyanous acid) respectively. Specificity constants indicate that SCN(−) is a major substrate for MPO. HOSCN is also a major o...

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Detalles Bibliográficos
Autores principales: Lane, Amanda E., Tan, Joanne T. M., Hawkins, Clare L., Heather, Alison K., Davies, Michael J.
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911680/
https://www.ncbi.nlm.nih.gov/pubmed/20528774
http://dx.doi.org/10.1042/BJ20100082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911680/
https://www.ncbi.nlm.nih.gov/pubmed/20528774
http://dx.doi.org/10.1042/BJ20100082

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