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Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts
INTRODUCTION: It has been proposed that individual genetic variation contributes to the course of severe infections and sepsis. Recent studies of single nucleotide polymorphisms (SNPs) within the endotoxin receptor and its signaling system showed an association with the risk of disease development....
Autores principales: | Kumpf, Oliver, Giamarellos-Bourboulis, Evangelos J, Koch, Alexander, Hamann, Lutz, Mouktaroudi, Maria, Oh, Djin-Ye, Latz, Eicke, Lorenz, Eva, Schwartz, David A, Ferwerda, Bart, Routsi, Christina, Skalioti, Chryssanthi, Kullberg, Bart-Jan, van der Meer, Jos WM, Schlag, Peter M, Netea, Mihai G, Zacharowski, Kai, Schumann, Ralf R |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911747/ https://www.ncbi.nlm.nih.gov/pubmed/20525286 http://dx.doi.org/10.1186/cc9047 |
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