Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

INTRODUCTION: Type 4 phosphodiesterases (PDE4) play an important role in immune cells through the hydrolysis of the second messenger, cAMP. Inhibition of PDE4 has previously been shown to suppress immune and inflammatory responses, demonstrating PDE4 to be a valid therapeutic target for immune-media...

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Detalles Bibliográficos
Autores principales: McCann, Fiona E, Palfreeman, Andrew C, Andrews, Melanie, Perocheau, Dany P, Inglis, Julia J, Schafer, Peter, Feldmann, Marc, Williams, Richard O, Brennan, Fionula M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911898/
https://www.ncbi.nlm.nih.gov/pubmed/20525198
http://dx.doi.org/10.1186/ar3041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911898/
https://www.ncbi.nlm.nih.gov/pubmed/20525198
http://dx.doi.org/10.1186/ar3041

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