Cargando…

Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis

INTRODUCTION: Type 4 phosphodiesterases (PDE4) play an important role in immune cells through the hydrolysis of the second messenger, cAMP. Inhibition of PDE4 has previously been shown to suppress immune and inflammatory responses, demonstrating PDE4 to be a valid therapeutic target for immune-media...

Descripción completa

Detalles Bibliográficos
Autores principales:	McCann, Fiona E, Palfreeman, Andrew C, Andrews, Melanie, Perocheau, Dany P, Inglis, Julia J, Schafer, Peter, Feldmann, Marc, Williams, Richard O, Brennan, Fionula M
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911898/ https://www.ncbi.nlm.nih.gov/pubmed/20525198 http://dx.doi.org/10.1186/ar3041

Ejemplares similares

New developments in the management of psoriasis and psoriatic arthritis: a focus on apremilast
por: Palfreeman, Andrew C, et al.
Publicado: (2013)

Resting CD4(+ )effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function
por: Brennan, Fionula M, et al.
Publicado: (2008)

Cytokine regulation in RA synovial tissue: role of T cell/macrophage contact-dependent interactions
por: Brennan, Fionula Mary, et al.
Publicado: (2002)

Apremilast, a novel phosphodiesterase 4 (PDE4) inhibitor, regulates inflammation through multiple cAMP downstream effectors
por: Perez-Aso, Miguel, et al.
Publicado: (2015)

In memoriam: Professor Brian Maurice John Foxwell, 1956 to 2008
por: Brennan, Fionula, et al.
Publicado: (2009)

Genotoxic potential of a novel PDE-4B inhibitor Apremilast by chromosomal aberration and micronucleus assay in mice
por: Afzal, Muhammad, et al.
Publicado: (2020)

Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis
por: Foey, Andrew, et al.
Publicado: (2002)

The Role of TNFα in the Pathogenesis of Rheumatoid Synovitis
por: Maini, Ravinder N, et al.
Publicado: (2000)

Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor: A novel treatment option for nurse practitioners treating patients with psoriatic disease
por: Young, Melodie, et al.
Publicado: (2016)

Apremilast ameliorates ox-LDL-induced endothelial dysfunction mediated by KLF6
por: Wang, Hao, et al.
Publicado: (2020)

Apremilast ameliorates IL-1α-induced dysfunction in epidermal stem cells
por: Jia, Yuxi, et al.
Publicado: (2021)

Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis
por: Kawabata, Tomoko, et al.
Publicado: (2010)

Impact of VIP and cAMP on the regulation of TNF-α and IL-10 production: implications for rheumatoid arthritis
por: Foey, Andrew D, et al.
Publicado: (2003)

Apremilast ameliorates acute respiratory distress syndrome by inhibiting neutrophil-induced oxidative stress
por: Tsai, Yung-Fong, et al.
Publicado: (2023)

Increased Autophagy Enhances the Resistance to Tumor Necrosis Factor-Alpha Treatment in Rheumatoid Arthritis Human Fibroblast-Like Synovial Cell
por: Dai, Yujie, et al.
Publicado: (2018)

Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
por: Notley, Clare A., et al.
Publicado: (2008)

Recent developments in the immunobiology of rheumatoid arthritis
por: Andersson, Anna K, et al.
Publicado: (2008)

Pediatric psoriasis treated with apremilast
por: Smith, Rebecca L.
Publicado: (2016)

Erythrodermic Psoriasis Treated with Apremilast
por: Arcilla, John, et al.
Publicado: (2016)

Repigmentation of Tenacious Vitiligo on Apremilast
por: Huff, Sara B., et al.
Publicado: (2017)

Apremilast in Refractory Alopecia Areata
por: Estébanez, Andrea, et al.
Publicado: (2019)

Treatment of erythrodermic psoriasis with apremilast
por: Gioe, Olivia A., et al.
Publicado: (2021)

IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production
por: Blazek, Katrina, et al.
Publicado: (2015)

Large-scale Analyses of Disease Biomarkers and Apremilast Pharmacodynamic Effects
por: Medvedeva, Irina V., et al.
Publicado: (2020)

Baicalein Ameliorates Aβ-Induced Memory Deficits and Neuronal Atrophy via Inhibition of PDE2 and PDE4
por: Shi, Jing, et al.
Publicado: (2021)

Resistance of rheumatoid arthritis synovial fibroblasts to p38 MAP-kinase inhibition of pro-destructive functions mediated by tumor necrosis factor alpha/tumor necrosis factor receptor-1
por: Kunisch, E, et al.
Publicado: (2005)

Worsening of Lymphopenia during Apremilast Treatment
por: Kolios, Antonios G.A., et al.
Publicado: (2016)

Apremilast for treatment of recalcitrant aphthous stomatitis
por: Schibler, Fabian, et al.
Publicado: (2017)

Apremilast as an adjuvant therapy for calcinosis cutis
por: Qiblawi, Sultan H., et al.
Publicado: (2019)

Treatment of a perforating dermatosis with apremilast
por: McMichael, Josette, et al.
Publicado: (2021)

Apremilast in the Management of Disseminated Granuloma Annulare
por: Joshi, Tejas P, et al.
Publicado: (2021)

Beneficial Impact of Apremilast on Palmoplantar Keratodermas
por: NAKAJIMA, Kimiko, et al.
Publicado: (2021)

Treatment of pyoderma gangrenosum with apremilast monotherapy
por: Bordeaux, Zachary A., et al.
Publicado: (2022)

Apremilast or Methotrexate: The Arrows in the Quiver for Psoriasis
por: Panda, Gautam, et al.
Publicado: (2023)

The pharmacokinetic effect of coadministration of apremilast and methotrexate in individuals with rheumatoid arthritis and psoriatic arthritis
por: Liu, Yong, et al.
Publicado: (2014)

A follow-up to "Anti-cytokine therapy in chronic destructive arthritis" by Wim B van den Berg
por: Brennan, Fionula M
Publicado: (2001)

Design and Optimisation of Bioactive Cyclic Peptides: Generation of a Down-Regulator of TNF Secretion
por: New, Roger, et al.
Publicado: (2014)

Activation of PDE10 and PDE11
por: Jäger, Ronald, et al.
Publicado: (2011)

Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor
por: Ernestam, Sofia, et al.
Publicado: (2006)

Apremilast Ameliorates Experimental Arthritis via Suppression of Th1 and Th17 Cells and Enhancement of CD4(+)Foxp3(+) Regulatory T Cells Differentiation
por: Chen, Weiqian, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_l4bcoej6k38tv8eu32of1h3qjv