Cargando…

Modification of hERG1 channel gating by Cd(2+)

Each of the four subunits in a voltage-gated potassium channel has a voltage sensor domain (VSD) that is formed by four transmembrane helical segments (S1–S4). In response to changes in membrane potential, intramembrane displacement of basic residues in S4 produces a gating current. As S4 moves thro...

Descripción completa

Detalles Bibliográficos
Autores principales: Abbruzzese, Jennifer, Sachse, Frank B., Tristani-Firouzi, Martin, Sanguinetti, Michael C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912066/
https://www.ncbi.nlm.nih.gov/pubmed/20660661
http://dx.doi.org/10.1085/jgp.201010450