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Modification of hERG1 channel gating by Cd(2+)
Each of the four subunits in a voltage-gated potassium channel has a voltage sensor domain (VSD) that is formed by four transmembrane helical segments (S1–S4). In response to changes in membrane potential, intramembrane displacement of basic residues in S4 produces a gating current. As S4 moves thro...
Autores principales: | Abbruzzese, Jennifer, Sachse, Frank B., Tristani-Firouzi, Martin, Sanguinetti, Michael C. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912066/ https://www.ncbi.nlm.nih.gov/pubmed/20660661 http://dx.doi.org/10.1085/jgp.201010450 |
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