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Ion permeation and block of the gating pore in the voltage sensor of Na(V)1.4 channels with hypokalemic periodic paralysis mutations
Hypokalemic periodic paralysis and normokalemic periodic paralysis are caused by mutations of the gating charge–carrying arginine residues in skeletal muscle Na(V)1.4 channels, which induce gating pore current through the mutant voltage sensor domains. Inward sodium currents through the gating pore...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912069/ https://www.ncbi.nlm.nih.gov/pubmed/20660662 http://dx.doi.org/10.1085/jgp.201010414 |