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Dendritic Cells Transduced to Express Interleukin 4 Reduce Diabetes Onset in Both Normoglycemic and Prediabetic Nonobese Diabetic Mice

BACKGROUND: We and others have previously demonstrated that treatment with bone marrow derived DC genetically modified to express IL-4 reduce disease pathology in mouse models of collagen-induced arthritis and delayed-type hypersensitivity. Moreover, treatment of normoglycemic NOD mice with bone mar...

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Detalles Bibliográficos
Autores principales: Ruffner, Melanie A., Robbins, Paul D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912295/
https://www.ncbi.nlm.nih.gov/pubmed/20686610
http://dx.doi.org/10.1371/journal.pone.0011848