Forced Homo- and Heterodimerization of All gp130-Type Receptor Complexes Leads to Constitutive Ligand-independent Signaling and Cytokine-independent Growth

Naturally ligand independent constitutively active gp130 variants were described to be responsible for inflammatory hepatocellular adenomas. Recently, we genetically engineered a ligand-independent constitutively active gp130 variant based on homodimerization of Jun leucine zippers. Because also het...

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Detalles Bibliográficos
Autores principales: Suthaus, Jan, Tillmann, Anna, Lorenzen, Inken, Bulanova, Elena, Rose-John, Stefan, Scheller, Jürgen
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2010
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912364/
https://www.ncbi.nlm.nih.gov/pubmed/20554759
http://dx.doi.org/10.1091/mbc.E10-03-0240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912364/
https://www.ncbi.nlm.nih.gov/pubmed/20554759
http://dx.doi.org/10.1091/mbc.E10-03-0240

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