The Fitness Landscapes of cis-Acting Binding Sites in Different Promoter and Environmental Contexts

The biophysical nature of the interaction between a transcription factor and its target sequences in vitro is sufficiently well understood to allow for the effects of DNA sequence alterations on affinity to be predicted. But even in relatively simple in vivo systems, the complexities of promoter org...

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Detalles Bibliográficos
Autores principales: Shultzaberger, Ryan K., Malashock, Daniel S., Kirsch, Jack F., Eisen, Michael B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912393/
https://www.ncbi.nlm.nih.gov/pubmed/20686658
http://dx.doi.org/10.1371/journal.pgen.1001042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912393/
https://www.ncbi.nlm.nih.gov/pubmed/20686658
http://dx.doi.org/10.1371/journal.pgen.1001042

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