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Molecular Evolution of the Primate Antiviral Restriction Factor Tetherin

BACKGROUND: Tetherin is a recently identified antiviral restriction factor that restricts HIV-1 particle release in the absence of the HIV-1 viral protein U (Vpu). It is reminiscent of APOBEC3G and TRIM5a that also antagonize HIV. APOBEC3G and TRIM5a have been demonstrated to evolve under pervasive...

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Detalles Bibliográficos
Autores principales: Liu, Jun, Chen, Keping, Wang, Jian-Hua, Zhang, Chiyu
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2912774/
https://www.ncbi.nlm.nih.gov/pubmed/20689591
http://dx.doi.org/10.1371/journal.pone.0011904