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Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli

Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challenging as changes in fitness may result from perturbations to many pathways, any of which may contribute relatively little. We have developed a combined...

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Detalles Bibliográficos
Autores principales: Goodarzi, Hani, Bennett, Bryson D, Amini, Sasan, Reaves, Marshall L, Hottes, Alison K, Rabinowitz, Joshua D, Tavazoie, Saeed
Formato: Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913397/
https://www.ncbi.nlm.nih.gov/pubmed/20531407
http://dx.doi.org/10.1038/msb.2010.33