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Upregulation of Endogenous HMOX1 Expression by a Computer-Designed Artificial Transcription Factor

Heme oxygenase-1 (HO-1) is well known as a cytoprotective factor. Research has revealed that it is a promising therapeutic target for cardiovascular diseases. In the current study, an HMOX1 (HO-1 gene) enhancer-specific artificial zinc-finger protein (AZP) was designed using bioinformatical methods....

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Detalles Bibliográficos
Autores principales: Guo, Hongfeng, Tian, Yi, Lu, Hai, Wei, Yong, Ying, Dajun
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913762/
https://www.ncbi.nlm.nih.gov/pubmed/20706680
http://dx.doi.org/10.1155/2010/168689