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The nuclear import of Frizzled2-C by Importins-β11 and α2 promotes postsynaptic development
Synapse-to-nucleus signaling is critical for synaptic development and plasticity. In Drosophila, the ligand Wingless causes the C-terminus of its Frizzled2 receptor (Fz2-C) to be cleaved and translocated from the postsynaptic density to nuclei. The mechanism of nuclear import is unknown and the deve...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913881/ https://www.ncbi.nlm.nih.gov/pubmed/20601947 http://dx.doi.org/10.1038/nn.2593 |