Structure and Reactivity of Bacillus subtilis MenD Catalyzing the First Committed Step in Menaquinone Biosynthesis

The first committed step in the classical biosynthetic route to menaquinone (vitamin K(2)) is a Stetter-like conjugate addition of α-ketoglutarate with isochorismate. This reaction is catalyzed by the thiamine diphosphate and metal-ion-dependent 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-...

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Detalles Bibliográficos
Autores principales: Dawson, Alice, Chen, Minjiao, Fyfe, Paul K., Guo, Zhihong, Hunter, William N.
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914249/
https://www.ncbi.nlm.nih.gov/pubmed/20600129
http://dx.doi.org/10.1016/j.jmb.2010.06.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914249/
https://www.ncbi.nlm.nih.gov/pubmed/20600129
http://dx.doi.org/10.1016/j.jmb.2010.06.025

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