Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans

BACKGROUND: The gene daf-2 encodes the single insulin/insulin growth factor-1-like receptor of Caenorhabditis elegans. The reduction-of-function allele e1370 induces several metabolic alterations and doubles lifespan. RESULTS: We found that the e1370 mutation alters aerobic energy production substan...

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Detalles Bibliográficos
Autores principales: Brys, Kristel, Castelein, Natascha, Matthijssens, Filip, Vanfleteren, Jacques R, Braeckman, Bart P
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914644/
https://www.ncbi.nlm.nih.gov/pubmed/20584279
http://dx.doi.org/10.1186/1741-7007-8-91

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914644/
https://www.ncbi.nlm.nih.gov/pubmed/20584279
http://dx.doi.org/10.1186/1741-7007-8-91

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