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Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans
BACKGROUND: The gene daf-2 encodes the single insulin/insulin growth factor-1-like receptor of Caenorhabditis elegans. The reduction-of-function allele e1370 induces several metabolic alterations and doubles lifespan. RESULTS: We found that the e1370 mutation alters aerobic energy production substan...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914644/ https://www.ncbi.nlm.nih.gov/pubmed/20584279 http://dx.doi.org/10.1186/1741-7007-8-91 |