Monoclonal antibody 4C5 prevents activation of MMP2 and MMP9 by disrupting their interaction with extracellular HSP90 and inhibits formation of metastatic breast cancer cell deposits

BACKGROUND: Heat shock protein 90 (HSP90) is a molecular chaperone that is considered a new target for the treatment of cancer. Increasing data reveal an extracellular chaperoning activity for HSP90. Here we investigate the interaction of the secreted isoforms of HSP90 with matrix metalloproteinases...

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Detalles Bibliográficos
Autores principales: Stellas, Dimitris, El Hamidieh, Avraam, Patsavoudi, Evangelia
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914660/
https://www.ncbi.nlm.nih.gov/pubmed/20602761
http://dx.doi.org/10.1186/1471-2121-11-51

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914660/
https://www.ncbi.nlm.nih.gov/pubmed/20602761
http://dx.doi.org/10.1186/1471-2121-11-51

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