Transgenic Overexpression of Active Calcineurin in β-Cells Results in Decreased β-Cell Mass and Hyperglycemia

BACKGROUND: Glucose modulates β-cell mass and function through an initial depolarization and Ca(2+) influx, which then triggers a number of growth regulating signaling pathways. One of the most important downstream effectors in Ca(2+) signaling is the calcium/Calmodulin activated serine threonine ph...

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Detalles Bibliográficos
Autores principales: Bernal-Mizrachi, Ernesto, Cras-Méneur, Corentin, Ye, Bo Ra, Johnson, James D., Permutt, M. Alan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914754/
https://www.ncbi.nlm.nih.gov/pubmed/20689817
http://dx.doi.org/10.1371/journal.pone.0011969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914754/
https://www.ncbi.nlm.nih.gov/pubmed/20689817
http://dx.doi.org/10.1371/journal.pone.0011969

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