Phage-Derived Fully Human Monoclonal Antibody Fragments to Human Vascular Endothelial Growth Factor-C Block Its Interaction with VEGF Receptor-2 and 3

Vascular endothelial growth factor C (VEGF-C) is a key mediator of lymphangiogenesis, acting via its receptors VEGF-R2 and VEGF-R3. High expression of VEGF-C in tumors correlates with increased lymphatic vessel density, lymphatic vessel invasion, sentinel lymph node metastasis and poor prognosis. Re...

Descripción completa

Detalles Bibliográficos
Autores principales: Rinderknecht, Matthias, Villa, Alessandra, Ballmer-Hofer, Kurt, Neri, Dario, Detmar, Michael
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914788/
https://www.ncbi.nlm.nih.gov/pubmed/20689828
http://dx.doi.org/10.1371/journal.pone.0011941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914788/
https://www.ncbi.nlm.nih.gov/pubmed/20689828
http://dx.doi.org/10.1371/journal.pone.0011941

Ejemplares similares