Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders

Strong genetic evidence implicates mutations and polymorphisms in the gene Disrupted-In-Schizophrenia-1 (DISC1) as risk factors for both schizophrenia and mood disorders. Recent studies have shown that DISC1 has important functions in both brain development and adult brain function. We have describe...

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Detalles Bibliográficos
Autores principales: Ayhan, Y, Abazyan, B, Nomura, J, Kim, R, Ladenheim, B, Krasnova, I N, Sawa, A, Margolis, R L, Cadet, J L, Mori, S, Vogel, M W, Ross, C A, Pletnikov, M V
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914807/
https://www.ncbi.nlm.nih.gov/pubmed/20048751
http://dx.doi.org/10.1038/mp.2009.144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914807/
https://www.ncbi.nlm.nih.gov/pubmed/20048751
http://dx.doi.org/10.1038/mp.2009.144

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